Re : Trying to push a script that writes to registry. Works when I run locally, not when I push via Desktop Central

Thank you for raising the post. As I can see your script is User profile based script as it changes HKCU hive on registry level, please try deploying using User Custom Script configuration rather Computer configuration.

Go to Configurations > Windows > Custom Script > User. Set the Target to required User account and perform the deployment. 

Try the above suggestion and let me know the status.

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Jai Kishan

Sr. Technical Consultant 

Desktop and Mobile Device Management Solution

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